Tetrahydrofuran → 2-{2-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-2-hydroxy-ethyl}-thiazole-5-carboxylic acid

反応式

[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:10][CH2:11][CH2:12][CH2:13][Li:14].[CH3:1][c:2]1[s:3][c:4]([C:7](=[O:8])[OH:9])[cH:5][n:6]1.[F:15][c:16]1[cH:17][cH:18][c:19](-[c:22]2[n:23][o:24][c:25]([CH3:29])[c:26]2[CH:27]=[O:28])[n:20][cH:21]1>>[CH2:1]([c:2]1[s:3][c:4]([C:7](=[O:8])[OH:9])[cH:5][n:6]1)[CH:27]([c:26]1[c:22](-[c:19]2[cH:18][cH:17][c:16]([F:15])[cH:21][n:20]2)[n:23][o:24][c:25]1[CH3:29])[OH:28]