Trifluoroacetic acid → 3,3-Dimethylpiperidin-4-one

HRID 12250

反応式

HRID 12250 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[O:14])[C:10]([CH3:16])([CH3:15])[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:15][C:10]1([CH3:16])[C:11](=[O:14])[CH2:12][CH2:13][NH:8][CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acid2 回HCID 22278899tert-Butyl 3,3-dimethyl-4-oxopiperidine-1-carboxylate

生成物 1

HCID 222788373,3-Dimethylpiperidin-4-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The 3,3-dimethyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester thus prepared (450 mg, 1.97 mmol) was dissolved in methylene chloride (10 mL). Trifluoroacetic acid was added (305 uL) and the resulting solution stirred at room temperature 2 h. Additional trifluoroacetic acid was added (300 uL) and the reaction stirred at room temperature 3 days. The pale yellow solution was concentrated to afford an oily residue, which was triturated with ether. The solids were collected by suction filtration and dried in vacuo. 3,3-Dimethyl-piperidin-4-one was isolated and used as its trifluoroacetic acid salt (381 mg, 80%).

後処理

  1. stirringthe reaction stirred at room temperature 3 days
  2. concentrationThe pale yellow solution was concentrated
  3. customto afford an oily residue, which
  4. customwas triturated with ether
  5. filtrationThe solids were collected by suction filtration
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-56dffb8badf046c4b6812a170c7583af
出典データセット
uspto-grants-2010_06
特許番号
US07727985B2

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