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HRID 12268作成日：2026年10月26日
1,3-Diethyl 2-oxopropanedioate → Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate
https://huagongshe.com/reaction/12268
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,3-Diethyl 2-oxopropanedioate | HCID 69105 | — |
| 反応物 | 1-(2-(Ethylamino)pyrimidin-4-yl)ethanone | HCID 68452125 | — |
| 生成物 | Diethyl 2-[2-(2-ethylaminopyrimidin-4-yl)-2-oxo-ethyl]-2-hydroxymalonate | HCID 68452836 | — |
反応手順
A mixture consisting of 1.9 g of 1-(2-ethylaminopyrimidin-4-yl)ethanone and 1.86 ml of diethyl ketomalonate is heated at 110° C. for 18 hours. The mixture is purified by column chromatography (silica gel, mobile phase:methylene chloride:methanol=98:2).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07727989B2 |
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| 出典データセット | uspto-grants-2010_06 |
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| ORD ID | ord-0d9dbd0ceb884aa9952e31fab8bb9478 |
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| 出典メモ | uspto-grants-2010_06 |
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