Bromomethylcyclopropane → 4-[5-[[4a-(Cyclopropylmethoxymethyl)-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinolin-6-yl]sulfonyl]-2-pyridinyl]morpholine

反応式

[CH:38]1([CH2:41][Br:42])[CH2:39][CH2:40]1.[F:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[n:9][cH:10][c:11]3[c:12]2[CH:13]=[C:14]2[CH2:15][CH2:16][N:17]([S:23](=[O:24])(=[O:25])[c:26]4[cH:27][n:28][c:29]([N:32]5[CH2:33][CH2:34][O:35][CH2:36][CH2:37]5)[cH:30][cH:31]4)[CH2:18][C:19]2([CH2:21][OH:22])[CH2:20]3)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[n:8]2[n:9][cH:10][c:11]3[c:12]2[CH:13]=[C:14]2[CH2:15][CH2:16][N:17]([S:23](=[O:24])(=[O:25])[c:26]4[cH:27][n:28][c:29]([N:32]5[CH2:33][CH2:34][O:35][CH2:36][CH2:37]5)[cH:30][cH:31]4)[CH2:18][C:19]2([CH2:21][O:22][CH2:41][CH:38]2[CH2:39][CH2:40]2)[CH2:20]3)[cH:6][cH:7]1

参加物

反応物 2

HCID 81503Bromomethylcyclopropane

HCID 66780234[1-(4-Fluorophenyl)-6-[(6-morpholin-4-yl-3-pyridinyl)sulfonyl]-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinolin-4a-yl]methanol

生成物 1

HCID 667795534-[5-[[4a-(Cyclopropylmethoxymethyl)-1-(4-fluorophenyl)-4,5,7,8-tetrahydropyrazolo[5,4-g]isoquinolin-6-yl]sulfonyl]-2-pyridinyl]morpholine

出典と根拠

ORDレコード: ord-524368a4af004b7ebb35dfb8487b5f73
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…