Tetrahydrofuran → 2-{2-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-yl]-2-hydroxy-ethyl}-4-methyl-thiazole-5-carboxylic acid

反応式

[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:11][CH2:12][CH2:13][CH2:14][Li:15].[CH3:1][c:2]1[s:3][c:4]([C:8](=[O:9])[OH:10])[c:5]([CH3:7])[n:6]1.[F:16][c:17]1[cH:18][cH:19][c:20](-[c:23]2[n:24][o:25][c:26]([CH3:30])[c:27]2[CH:28]=[O:29])[n:21][cH:22]1>>[CH2:1]([c:2]1[s:3][c:4]([C:8](=[O:9])[OH:10])[c:5]([CH3:7])[n:6]1)[CH:28]([c:27]1[c:23](-[c:20]2[cH:19][cH:18][c:17]([F:16])[cH:22][n:21]2)[n:24][o:25][c:26]1[CH3:30])[OH:29]