Dichloromethane → 2-methylpropyl N-[1-[6-fluoro-2-(2-hydroxyphenyl)quinazolin-4-yl]pyrrolidin-3-yl]carbamate

反応式

[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cl:32][C:33](=[O:34])[O:35][CH2:36][CH:37]([CH3:38])[CH3:39].[Cl:40][CH2:41][Cl:42].[NH2:8][CH:9]1[CH2:10][N:11]([c:14]2[n:15][c:16](-[c:25]3[c:26]([OH:31])[cH:27][cH:28][cH:29][cH:30]3)[n:17][c:18]3[cH:19][cH:20][c:21]([F:24])[cH:22][c:23]23)[CH2:12][CH2:13]1>>[NH:8]([CH:9]1[CH2:10][N:11]([c:14]2[n:15][c:16](-[c:25]3[c:26]([OH:31])[cH:27][cH:28][cH:29][cH:30]3)[n:17][c:18]3[cH:19][cH:20][c:21]([F:24])[cH:22][c:23]23)[CH2:12][CH2:13]1)[C:33](=[O:34])[O:35][CH2:36][CH:37]([CH3:38])[CH3:39]