Cyclohexylamine → Ethyl 3-(cyclohexylamino)propanoate

HRID 12348

反応式

HRID 12348 の反応式
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:8]([O:10][C:11](=[O:15])[CH2:12][CH2:13]Cl)[CH3:9].C([O-])([O-])=O.[K+].[K+]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH2:8]([O:10][C:11](=[O:15])[CH2:12][CH2:13][NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH3:9]

参加物

5

反応物 3

HCID 7965CyclohexylamineHCID 11430Potassium CarbonateHCID 69341Ethyl 3-chloropropionate

生成物 1

HCID 243063Ethyl 3-(cyclohexylamino)propanoate収率 72.3%

試薬・触媒・溶媒 1

HCID 67553Tetrabutylammonium Iodide触媒

反応条件

温度
80 °C

実験手順

Cyclohexylamine (0.86 g, 8.7 mmol) and 3-chloro-propionic acid ethyl ester (1.18 g, 8.67 mmol) were combined neat and K2CO3 (1.2 g, 8.7 mmol) and a catalytic amount of tetrabutylammonium iodide (ca. 5 mg) was added. The mixture was heated at 80° C. overnight. The resulting mixture was then partitioned between water and dichloromethane. The organic layer was dried (MgSO4) and concentrated to afford 1.25 g (72%) of the title compound.

後処理

  1. customThe resulting mixture was then partitioned between water and dichloromethane
  2. dry with materialThe organic layer was dried (MgSO4)
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-66ca2717a0e24c2293f8cef297ade30e
出典データセット
uspto-grants-2010_06
特許番号
US07728003B2

関連ノート

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