Cyclohexylamine → Ethyl 3-(cyclohexylamino)propanoate
反応式
[CH:1]1([NH2:7])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:8]([O:10][C:11](=[O:15])[CH2:12][CH2:13]Cl)[CH3:9].C([O-])([O-])=O.[K+].[K+]>[I-].C([N+](CCCC)(CCCC)CCCC)CCC>[CH2:8]([O:10][C:11](=[O:15])[CH2:12][CH2:13][NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[CH3:9]参加物
5
反応条件
- 温度
- 80 °C
実験手順
Cyclohexylamine (0.86 g, 8.7 mmol) and 3-chloro-propionic acid ethyl ester (1.18 g, 8.67 mmol) were combined neat and K2CO3 (1.2 g, 8.7 mmol) and a catalytic amount of tetrabutylammonium iodide (ca. 5 mg) was added. The mixture was heated at 80° C. overnight. The resulting mixture was then partitioned between water and dichloromethane. The organic layer was dried (MgSO4) and concentrated to afford 1.25 g (72%) of the title compound.
後処理
- customThe resulting mixture was then partitioned between water and dichloromethane
- dry with materialThe organic layer was dried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-66ca2717a0e24c2293f8cef297ade30e
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07728003B2
反応ノート
読み込み中…