2-Methoxyethylamine → 8-Cyclohexyl-5-oxo-2-(2-methoxy-ethylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester
反応式
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[CH2:6]([O:8][C:9]([C:11]1[C:12](=[O:31])[C:13]2[CH:18]=[N:17][C:16](S(C)(=O)=O)=[N:15][C:14]=2[N:23]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[CH:24]=1)=[O:10])[CH3:7]>>[CH2:6]([O:8][C:9]([C:11]1[C:12](=[O:31])[C:13]2[CH:18]=[N:17][C:16]([NH:5][CH2:4][CH2:3][O:2][CH3:1])=[N:15][C:14]=2[N:23]([CH:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[CH:24]=1)=[O:10])[CH3:7]参加物
3
実験手順
Using the procedure outlined in Example 28 Step F, the title compound was prepared from 2-methoxy-ethylamine and 8-cyclohexyl-2-methanesulfonyl-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester (27 mg, 0.07 mmol). 8-Cyclohexyl-5-oxo-2-(2-methoxy-ethylamino)-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester was obtained as a white solid (20 mg, 80%). Mass Spectrum (LCMS, ESI pos.) Calcd. For C19H26N4O4: 375.2 (M+H). Found: 375.2.