2-Methoxyethylamine (HCID 8018)

名称と識別子

優先名称: 2-Methoxyethylamine
IUPAC: 2-methoxyethanamine
現地名: 2-メトキシエチルアミン
英語名: 2-Methoxyethylamine
分子式: C3H9NO
分子量: 75.11

名称と別名

2-Methoxyethylamine2-MethoxyethanamineEthanamine, 2-methoxy-METHOXYETHYLAMINEBRN 0741854EINECS 203-712-1UNII-743U9W3NIL743U9W3NILAI3-24230AI3-524722-methoxy-1-aminoethanen-(2-methoxyethyl)amine

名称をさらに表示

2-メトキシエチルアミンO-メチルエタノールアミンメチル2-アミノエチルエーテル2-アミノエチルメチルエーテル(2-メトキシエチル)アミン2-メトキシエタンアミン2-AMINOETHYL METHYL ETHERMethyl-PEG-amineCAS_109-85-32-methoxy-ethylamin2-methoxy-ethanaminRARECHEM AL BW 0200

CH3OCH2CH2NH2DTXSID1021908ASUDFOJKTJLAIK-UHFFFAOYSA-4-04-00-01411 (Beilstein Handbook Reference)2methoxyethanamine2Methoxy1ethanaminebetaMethoxyethylamine1Amino2methoxyethane

データベース識別子

CAS: 109-85-3
PubChem CID: 8018
DTXSID: DTXSID1021908
ChEMBL: CHEMBL4101550
UNII: 743U9W3NIL
EC Number: 203-712-1
Nikkaji: J46.395G

物性

構造計算による物性

XLogP: -0.9
極性表面積: 35.3 Å²
水素結合供与体数: 1
水素結合受容体数: 2
回転可能結合数: 2
重原子数: 5
形式電荷: 0
複雑度: 16.4

実験および物理化学的性質

Chemical ClassesNitrogen Compounds -> Other Nitrogen Compounds

SpringerMaterials PropertiesCoriolis coupling

Boiling Point95 °C @760 [mm Hg]

Physical DescriptionClear colorless liquid; [Sigma-Aldrich MSDS]

物理化学的性質

融点: -82 °C · -82 °C
沸点: 95 °C · 95 °C (lit.)
比重(密度): 0.864 g/mL · 0.864 g/mL at 25 °C (lit.)
屈折率: 20 · n20/D 1.406(lit.)
闪点: 49 °F · 49 °F
貯蔵温度: 30 °C · Store below +30°C.
水溶解度: Completely miscible in water
外見: clear liquid
酸解離定数(Pka): 9.89 · 9.89(at 10℃)
色: Colorless to Almost colorless
PH: 12 · 12 (100g/l, H2O, 20℃)
爆発限界(explosive limit): 3 · 3-16.10%(V)
BRN: 741854 · 741854
Henry's Law Constant: 2.5 · 2.5×101 mol/(m3Pa) at 25℃, Cabani et al. (1978)
InChI: 1S/C3H9NO/c1-5-3-2-4/h2-4H2,1H3
InChIKey: ASUDFOJKTJLAIK-UHFFFAOYSA-N
SMILES: COCCN
CAS データベース: 109 · 109-85-3(CAS DataBase Reference)
EPAの化学物質情報: 2 · Ethanamine, 2-methoxy- (109-85-3)

化学的性質

化学的特性clear colorless liquid

安全と法規制

GHS分類

GHS Classification · 4 件

Danger

H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 156 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information2-Methoxyethylamine: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1 件

A severe eye irritant; Causes muscle weakness, tremor, ataxia, dyspnea, and cyanosis in oral lethal-dose studies of rats and mice; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; [Sigma-Aldrich MSDS] See Ethanolamine.

Hazard Classes and CategoriesFlam. Liq. 2 (100%)

安全と保護具

Protective Action Criteria (PAC) · 3 件

1.3 [mg/m3]

14 [mg/m3]

87 [mg/m3]

毒性情報

Adverse EffectsDermatotoxin - Skin burns.

安全データ

wgk: 3
tsca: TSCA listed
rtecs: KR8750000
ridadr: UN 2733 3/PG 2
毒性: LD50 orally in Rabbit: 1570 mg/kg
hs_code: 29221990
risk_code: 11-34
消防法: 危-4-1-II
hazard_code: F,C
safety_code: 16-26-36/37/39-45
hazard_class: 3
packing_group: II
自然発火温度: 285 °C
Hazard Classifications: Acute Tox. 4 InhalationAcute Tox. 4 OralEye Dam. 1Flam. Liq. 2Skin Corr. 1B
ストレージクラス: 3 - Flammable liquids

化学と産業

用途と製造

General Manufacturing InformationEthanamine, 2-methoxy-: ACTIVE

応用分野

使用2-Methoxyethylamine is used as a reagent in the preparation of lipid-like materials for delivery of RNAi therapeutics.

一般的な説明Kinetics of reaction of 2-methoxyethylamine with guanosine 5′-phospho-2-methylimidazolide (2-MeImpG) was studied.

調製方法 · 1 件

純化方法An aqueous 70% solution of the amine is dehydrated by azeotropic distillation with *benzene or methylene chloride and the amine is distilled twice from zinc dust. Store it in a tight container as it absorbs CO2 from the atmosphere. [Beilstein 4 IV 1411.]