Sodium Hydroxide → N-[2-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]thiourea

HRID 12391ノート

反応式

HRID 12391 の反応式
C([NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[N:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:21]([CH3:29])([CH3:28])[CH2:20]1)=[S:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>CO>[CH3:28][C:21]1([CH3:29])[C:22]2[C:27](=[CH:26][CH:25]=[CH:24][CH:23]=2)[N:19]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:13]=2[NH:12][C:10]([NH2:9])=[S:11])[CH2:20]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 593377231-Benzoyl-3-(2-(3,3-dimethylindolin-1-yl)phenyl)thiourea

生成物 1

HCID 59337709N-[2-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]thiourea

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

To a solution of 2f (60 mg, 0.149 mmol) in MeOH was added 1N NaOH (0.2 mL, 0.2 mmol). The reaction mixture was stirred at 50° C. for 2 h. The solvent was evaporated under reduced pressure and co-evaporated with toluene to afford 2 g (35 mg, 80%). MS (ES) m/z 298 [M+H]30 .

後処理

  1. customThe solvent was evaporated under reduced pressure and co-evaporated with toluene
  2. customto afford 2 g (35 mg, 80%)

出典と根拠

ORDレコード
ord-b622ac2b97c445c8892456fc306c31a0
出典データセット
uspto-grants-2010_06
特許番号
US07728008B2

反応ノート

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