Dimethylformamide → t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate

HRID 12406

反応式

HRID 12406 の反応式
Cl[CH2:2][C@@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4].[F:13][C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1.C(=O)([O-])[O-].[K+].[K+].CN(C=O)C>C(OCC)(=O)C>[F:13][C:14]1[CH:15]=[C:16]([CH:17]=[CH:18][CH:19]=1)[O:20][CH2:2][C@@H:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH3:4]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 97433-FluorophenolHCID 11430Potassium CarbonateHCID 86761117t-butyl (1S)-2-chloro-1-methylethylcarbamate

生成物 1

HCID 86761118t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
95 °C

実験手順

To the compound (500 mg) obtained in Step 3 were added 3-fluorophenol (84 μl), potassium carbonate (250 mg) and DMF (2 ml), and the mixture was stirred overnight at 95° C. The reaction mixture was diluted with ethyl acetate. After washing with water, the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound as a crude product.

後処理

  1. washAfter washing with water
  2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-b140c6747a1a44558eefb386d2991521
出典データセット
uspto-grants-2010_06
特許番号
US07728005B2

関連ノート

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