関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 3-Fluorophenol | HCID 9743 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | t-butyl (1S)-2-chloro-1-methylethylcarbamate | HCID 86761117 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | t-butyl (1S)-2-(3-fluorophenoxy)-1-methylethylcarbamate | HCID 86761118 | — |
反応手順
To the compound (500 mg) obtained in Step 3 were added 3-fluorophenol (84 μl), potassium carbonate (250 mg) and DMF (2 ml), and the mixture was stirred overnight at 95° C. The reaction mixture was diluted with ethyl acetate. After washing with water, the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound as a crude product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07728005B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-b140c6747a1a44558eefb386d2991521 |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
