反应详情

温度

95 °C

To the compound (500 mg) obtained in Step 3 were added 3-fluorophenol (84 μl), potassium carbonate (250 mg) and DMF (2 ml), and the mixture was stirred overnight at 95° C. The reaction mixture was diluted with ethyl acetate. After washing with water, the organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated to give the title compound as a crude product.

1. washAfter washing with water
2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
3. customThe solvent was evaporated