Thionyl Chloride → 4-[(3,5-dimethylphenyl)-thio]-5-(chloromethyl)-6-methyl-2(1H)-pyridinone

HRID 1241537ノート

反応式

HRID 1241537 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[C:15]([CH2:16]O)=[C:14]([CH3:18])[NH:13][C:12](=[O:19])[CH:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1.O=S(Cl)[Cl:22]>ClCCl>[CH3:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[C:15]([CH2:16][Cl:22])=[C:14]([CH3:18])[NH:13][C:12](=[O:19])[CH:11]=2)[CH:5]=[C:6]([CH3:8])[CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 219352934-[(3,5-dimethylphenyl)-thio]-5-(hydroxymethyl)-6-methyl-2(1H)-pyridinone

生成物 1

HCID 219353114-[(3,5-dimethylphenyl)-thio]-5-(chloromethyl)-6-methyl-2(1H)-pyridinone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A suspension of intermediate 15 (275 mg; 1 mmol) in dichloromethane (10 ml) became homogeneous by addition of SOCl2 (2.3 ml) at room temperature. After 2 hours of stirring at room temperature, all the volatiles were removed under reduced pressure giving a yellow solid which corresponds to the expected intermediate 16 in quantitative yield (294 mg).

後処理

  1. customall the volatiles were removed under reduced pressure
  2. customgiving a yellow solid which

出典と根拠

ORDレコード
ord-06a659da66df4a499cb64409958e929e
出典データセット
uspto-grants-2006_10
特許番号
US07115608B2

反応ノート

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