4-(2-Methoxy-4-nitrophenyl)morpholine → 3-Methoxy-4-(morpholin-4-yl)aniline
反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N+:9]([O-])=O)[CH:6]=[CH:5][C:4]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>CCO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[CH:5][C:4]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1参加物
4
反応条件
- 温度
- 20 °C
実験手順
To a solution of 4-(2-methoxy-4-nitro-phenyl)-morpholine (1.0 g, 4.2 mmol, Step B) in EtOH (25 mL) at 20 ° C was added Pd/C (100 mg). The flask was capped with a rubber septum and H2 pressure was applied through a balloon/needle. The reaction mixture was stirred at 20° C. for 12 h, filtered through sand/Celite® and concentrated. Purification by chromatography of the crude mixture (97:3 CH2Cl2:MeOH) afforded 3-methoxy-4-morpholin-4-yl-phenylamine as a purple solid.
後処理
- customThe flask was capped with a rubber septum and H2 pressure
- filtrationfiltered through sand/Celite®
- concentrationconcentrated
- customPurification by chromatography of the crude mixture (97:3 CH2Cl2:MeOH)
出典と根拠
- ORDレコード
- ord-b26b8cb92a414b67b9477b84b3865068
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07115617B2
反応ノート
読み込み中…