3-Cyanophenyl isothiocyanate → 1-(3-Cyanophenyl)-3-(1,2,2-trimethyl-propyl)-thiourea

HRID 1241615

反応式

HRID 1241615 の反応式
[C:1]([C:3]1[CH:4]=[C:5]([N:9]=[C:10]=[S:11])[CH:6]=[CH:7][CH:8]=1)#[N:2].[CH3:12][C:13]([CH3:18])([CH3:17])[CH:14]([NH2:16])[CH3:15]>C1COCC1>[C:1]([C:3]1[CH:4]=[C:5]([NH:9][C:10]([NH:16][CH:14]([CH3:15])[C:13]([CH3:18])([CH3:17])[CH3:12])=[S:11])[CH:6]=[CH:7][CH:8]=1)#[N:2]

参加物

4

反応物 2

HCID 765783-Cyanophenyl isothiocyanateHCID 5209072-Butanamine, 3,3-dimethyl-

生成物 1

HCID 38203771-(3-Cyanophenyl)-3-(1,2,2-trimethyl-propyl)-thiourea収率 78%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 3-cyanophenyl isothiocyanate (1.00 g, 6.24 mmol) in THF (25 mL) at room temperature was added (±) 3,3-dimethyl-2-aminobutane (1.08 mL, 9.36 mmol) and the reaction was stirred overnight at room temperature. The mixture was concentrated in vacuo and the resulting residue was triturated with diethyl ether and filtered to afford 1.2 g (78%) of 1-(3-cyanophenyl)-3-(1,2,2-trimethyl-propyl)-thiourea as a white solid which was used without further purification.

後処理

  1. concentrationThe mixture was concentrated in vacuo
  2. customthe resulting residue was triturated with diethyl ether
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-c10838b872de494bbe742aea4651c8dc
出典データセット
uspto-grants-2006_10
特許番号
US07115620B2

関連ノート

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