Pyridine → HCID 21936632、化合物

HRID 1241716ノート

反応式

HRID 1241716 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][N:16]=3)[CH:11]=[C:10]([CH2:18][CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][N:24]=[CH:23][CH:22]=3)[C:9]2=[O:27])[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC=1.[C:34](OC(=O)C)(=[O:36])[CH3:35]>>[C:34]([NH:1][C:2]1[CH:3]=[C:4]([N:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][N:16]=3)[CH:11]=[C:10]([CH2:18][CH2:19][CH2:20][C:21]3[CH:22]=[CH:23][N:24]=[CH:25][CH:26]=3)[C:9]2=[O:27])[CH:5]=[CH:6][CH:7]=1)(=[O:36])[CH3:35]

参加物

4

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 21936625HCID 21936625、化合物

生成物 1

HCID 21936632HCID 21936632、化合物収率 82%

実験手順

1-(3-Aminophenyl)-3-[3-(pyridin-4-yl)propyl]-1,8-naphthyridin-2(1H)-one (100 mg, 0.28 mmol; prepared in Synthetic Example 7) was heated in acetic anhydride (0.5 ml) and pyridine (0.5 ml) at 100° C. for 20 min, concentrated, neutralized with saturated aqueous sodium hydrogen carbonate, and extracted with chloroform. The extract was treated according to conventional techniques. Recrystallization from DMF yielded 1-(3-acetylaminophenyl)-3-[3-(pyridin-4-yl)propyl]-1,8-naphthyridin-2(1H)-one (91.3 mg, 82%; mp 200–202° C./DMF).

後処理

  1. concentrationconcentrated
  2. extractionextracted with chloroform
  3. additionThe extract was treated
  4. customRecrystallization from DMF

出典と根拠

ORDレコード
ord-dbc2d1a5ca5540c6ad3673664d379517
出典データセット
uspto-grants-2006_10
特許番号
US07115623B2

反応ノート

読み込み中…