Trifluoroacetic acid → 2-(3-Methoxy-propyl)-4-methylamino-phenoxy-acetic acid ethyl ester

HRID 1242282ノート

反応式

HRID 1242282 の反応式
[CH2:1]([O:3][C:4](=[O:27])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13](C(OC(C)(C)C)=O)[CH3:14])=[CH:9][C:8]=1[CH2:22][CH2:23][CH2:24][O:25][CH3:26])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:27])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][CH3:14])=[CH:9][C:8]=1[CH2:22][CH2:23][CH2:24][O:25][CH3:26])[CH3:2]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 670721854-(tert-Butoxycarbonyl-methyl-amino)-2-(3-methoxy-propyl)-phenoxy-acetic acid ethyl ester

生成物 1

HCID 670721342-(3-Methoxy-propyl)-4-methylamino-phenoxy-acetic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1.55 g (4.06 mmol) of the above prepared [4-(tert-butoxycarbonyl-methyl-amino)-2-(3-methoxy-propyl)-phenoxy]-acetic acid ethyl ester was dissolved in 41 ml of CH2Cl2 and treated dropwise with 10 ml of TFA. After additional 30 Min. at RT, the bulk of the solvents was removed i. V. and the residue distributed between cold NaHCO3-solution and AcOEt. Washing with cold water and brine, drying over magnesium sulfate, and evaporation of the solvents left 1.15 g of the title compound as brownish oil which was used as such for the next step.

後処理

  1. customat RT, the bulk of the solvents was removed i
  2. washWashing with cold water and brine
  3. dry with materialdrying over magnesium sulfate, and evaporation of the solvents
  4. waitleft 1.15 g of the title compound as brownish oil which

出典と根拠

ORDレコード
ord-1caa9d6ba05742a2ab3592650969d7e8
出典データセット
uspto-grants-2006_10
特許番号
US07115611B2

反応ノート

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