2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde → [2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol

HRID 1242290ノート

反応式

HRID 1242290 の反応式
[CH3:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[N:3]=1.C[Mg]Cl>C1COCC1>[CH3:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][CH:5]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[CH:11]=2)[N:3]=1

参加物

4

反応物 2

HCID 219356242-Methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehydeHCID 178418332HCID 178418332、化合物

生成物 1

HCID 21935815[2-Methyl-6-(3-trifluoromethyl-phenyl)-pyridin-3-yl]-methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

0.500 g (1.89 mmol) of the above prepared 2-methyl-6-(3-trifluoromethyl-phenyl)-pyridine-3-carbaldehyde was dissolved in 9.4 ml of abs. THF and treated at −10° C. with 0.94 ml of 3M methyl magnesium chloride solution (in THF). After 30 Min., the reaction mixture was carefully poured onto crashed ice/NH4Cl, extracted twice with AcOEt, washed with water, dried over sodium sulfate, and evaporated to dryness to leave 0.532 g of the title product, pure according to NMR.

後処理

  1. dissolutionwas dissolved in 9.4 ml of abs
  2. addition, the reaction mixture was carefully poured
  3. extractionextracted twice with AcOEt
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-74950623264f439a9ef3f0974e9a6f9e
出典データセット
uspto-grants-2006_10
特許番号
US07115611B2

反応ノート

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