Sodium borohydride → (6-(4-(Trifluoromethoxy)phenyl)pyridin-3-YL)methanol

HRID 1242305ノート

反応式

HRID 1242305 の反応式
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:15]=[CH:14][C:13]([CH:16]=[O:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.[BH4-].[Na+]>CCO>[F:19][C:2]([F:1])([F:18])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[N:15]=[CH:14][C:13]([CH2:16][OH:17])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 219356276-[4-(Trifluoromethoxy)phenyl]-3-pyridinecarbaldehyde

生成物 1

HCID 21935933(6-(4-(Trifluoromethoxy)phenyl)pyridin-3-YL)methanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2.00 g (7.48 mmol) of commercially available 6-(4-trifluoromethoxy-phenyl)-pyridine-3-carbaldehyde was dissolved in 37 ml of EtOH and treated at 0° C. with 0.283 g (7.48 mmol) of NaBH4. After 10 Min. the cooling bath was removed and stirring continued at ambient temperature. Pouring onto crashed ice, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents afforded 2.08 g of pure title compound as off-white solid of mp. 57–58° C.

後処理

  1. customthe cooling bath was removed
  2. customcontinued at ambient temperature
  3. additionPouring
  4. extractionice, twofold extraction with AcOEt
  5. washwashing with water
  6. dry with materialdrying over sodium sulfate, and evaporation of the solvents

出典と根拠

ORDレコード
ord-e7a0896eb32c48dabd40056b2f32ed17
出典データセット
uspto-grants-2006_10
特許番号
US07115611B2

反応ノート

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