Thionyl Chloride → 5-Chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine
反応式
[CH3:1][O:2][CH2:3][CH2:4][C:5]1[C:10]([CH2:11]O)=[C:9]([CH3:13])[N:8]=[C:7]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)[N:6]=1.S(Cl)([Cl:26])=O>C(Cl)Cl>[Cl:26][CH2:11][C:10]1[C:5]([CH2:4][CH2:3][O:2][CH3:1])=[N:6][C:7]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=2)=[N:8][C:9]=1[CH3:13]参加物
4
実験手順
A solution of 2.47 g (7.48 mmol) [4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol in 25 ml Methylenchloride was treated with 0.57 ml (7.85 mmol) thionylchloride. After 2 h stirring at RT, the mixture was partitioned between ether and water. The ether-phase was concentrated under reduced pressure giving 2.42 g pure 5-chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine.