Thionyl Chloride → 5-Chloromethyl-4-methoxymethyl-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

HRID 1242511ノート

反応式

HRID 1242511 の反応式
[CH3:1][O:2][CH2:3][C:4]1[C:9]([CH2:10]O)=[C:8]([CH3:12])[N:7]=[C:6]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)[N:5]=1.S(Cl)([Cl:25])=O>>[Cl:25][CH2:10][C:9]1[C:4]([CH2:3][O:2][CH3:1])=[N:5][C:6]([C:13]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][CH:14]=2)=[N:7][C:8]=1[CH3:12]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 21935612HCID 21935612、化合物

生成物 1

HCID 219357575-Chloromethyl-4-methoxymethyl-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

実験手順

In analogy to the procedure described in example 113H], [4-methoxymethyl-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-methanol and thionylchloride gave the title compound as a light red oil.

出典と根拠

ORDレコード
ord-6a39d679356b4503b1b278257bca2508
出典データセット
uspto-grants-2006_10
特許番号
US07115611B2

反応ノート

読み込み中…