Aluminium lithium hydride → HCID 21935866、化合物

反応式

C[O:2][C:3](=O)[C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:7]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)=[N:6][CH:5]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:24][C:21]([F:22])([F:23])[O:20][C:17]1[CH:18]=[CH:19][C:14]([C:7]2[N:6]=[CH:5][C:4]([CH2:3][OH:2])=[C:9]([C:10]([F:13])([F:11])[F:12])[CH:8]=2)=[CH:15][CH:16]=1

参加物

実験手順

In analogy to the procedure described in example 43D], 6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid methyl ester was treated with lithium aluminium hydride in tetrahydrofuran under reflux conditions for 12 h to give the title compound as yellow oil.