Sodium Hydroxide → 2-(4-phenyl-1H-imidazol-1-yl)pyridine-3-carboxylic acid

HRID 12426ノート

反応式

HRID 12426 の反応式
[OH-].[Na+].[C:3]1([C:9]2[N:10]=[CH:11][N:12]([C:14]3[C:19]([C:20]([O:22]CC)=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:13]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO>[C:3]1([C:9]2[N:10]=[CH:11][N:12]([C:14]3[C:19]([C:20]([OH:22])=[O:21])=[CH:18][CH:17]=[CH:16][N:15]=3)[CH:13]=2)[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 66720067Ethyl 2-(4-phenyl-1H-imidazol-1-yl)pyridine-3-carboxylate

生成物 1

HCID 667200892-(4-phenyl-1H-imidazol-1-yl)pyridine-3-carboxylic acid収率 71.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

15 m of a 2N NaOH solution were added to a solution of 2.0 g of ethyl 2-(4-phenyl-1H-imidazol-1-yl)pyridine-3-carboxylate (6.82 mmol) in 30 ml of methanol, and the mixture was then stirred at room temperature for 2 hours. The reaction mixture was subsequently evaporated to dryness, mixed with 10 ml of H2O and neutralized by adding 2N HCl. Filtration with suction and drying the precipitate formed resulted in 1.3 g of the acid as brown amorphous solid.

後処理

  1. customThe reaction mixture was subsequently evaporated to dryness
  2. additionmixed with 10 ml of H2O
  3. additionby adding 2N HCl
  4. filtrationFiltration with suction
  5. customdrying the precipitate
  6. customformed

出典と根拠

ORDレコード
ord-99393151c1744845bf4cf1d3a6c2e56e
出典データセット
uspto-grants-2010_06
特許番号
US07728012B2

反応ノート

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