Trifluoroacetic acid → 116174-33-5

反応式

[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=O)[CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:5][CH:4]=1.FC(F)(F)C(O)=O.[H-].C([SiH](CC)CC)C>>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:8]=1

参加物

反応物 3

HCID 6422Trifluoroacetic acid

HCID 20637154-[4-(methylthio)phenyl]-4-oxobutanoic acid

HCID 131724811HCID 131724811、化合物

生成物 1

HCID 21916663116174-33-5

実験手順

A solution of the acid obtained in Step A (19.8 g, 88.1 mmol) in trifluoroacetic acid (68 ml, 881 mmol) is brought to 0° C. and then triethylsilane hydride (35.2 ml, 220 mmol) is added dropwise using a dropping funnel. Stirring is carried out at ambient temperature for 17 hours.