Tetrahydrofuran → HCID 21939867、化合物

反応式

[H-].[Al+3].[Li+].[H-].[H-].[H-].O1CCCC1.[C:12]([NH:15][C:16]1[CH:17]=[C:18]2[C:23](=[CH:24][CH:25]=1)[CH:22]=[C:21]([CH2:26][C:27](OC)=[O:28])[CH2:20][CH2:19]2)(=[O:14])[CH3:13]>C(OCC)(=O)C>[OH:28][CH2:27][CH2:26][C:21]1[CH2:20][CH2:19][C:18]2[CH:17]=[C:16]([NH:15][C:12](=[O:14])[CH3:13])[CH:25]=[CH:24][C:23]=2[CH:22]=1

参加物

実験手順

Lithium aluminum hydride (242 mg, 6.38 mmol) was added to a tetrahydrofuran solution (16 ml) of methyl [6-(acetylamino)-3,4-dihydro-2-naphthalenyl]acetate (827 mg, 3.19 mmol) obtained in Reference Example 101 under ice-cooling, which was stirred at room temperature for 1 hour. Ethyl acetate was added to the reaction mixture, which was washed with 1N hydrochloric acid and saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, and then the solvent was distilled out under reduced pressure. The residue was powdered with isopropyl ether, to give the titled compound (364 mg).