Sodium Azide → (R)-4-azido-1,1,1-trifluoro-2-butanol

HRID 1243613ノート

反応式

HRID 1243613 の反応式
[F:1][C:2]([F:9])([F:8])[C@H:3]([OH:7])[CH2:4][CH2:5]I.[N-:10]=[N+:11]=[N-:12].[Na+]>CS(C)=O.O>[N:10]([CH2:5][CH2:4][C@@H:3]([OH:7])[C:2]([F:9])([F:8])[F:1])=[N+:11]=[N-:12]

参加物

5

反応物 2

HCID 33557Sodium AzideHCID 22874097(R)-1,1,1-trifluoro-4-iodo-2-butanol

生成物 1

HCID 21064884(R)-4-azido-1,1,1-trifluoro-2-butanol収率 100.1%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

A solution of (R)-1,1,1-trifluoro-4-iodo-2-butanol (3.30 g, 13.0 mmol) in DMSO (22 mL) was treated with sodium azide (0.930 g, 14.3 mmol) at ambient temperature, followed by heating at 50° C. for 20 h. The mixture was diluted with cold water (250 mL) and extracted with diethyl ether. The combined organic extracts were washed (brine), dried, and evaporated without heat to give the product as a pale yellow oil (2.20 g, 100%).

後処理

  1. extractionextracted with diethyl ether
  2. washThe combined organic extracts were washed (brine)
  3. customdried
  4. customevaporated
  5. temperaturewithout heat

出典と根拠

ORDレコード
ord-d2c398c1965c4c7d87929722f998f964
出典データセット
uspto-grants-2006_10
特許番号
US07119109B2

反応ノート

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