Sodium Azide → 4-Azido-1,1,1-trifluoro-2-butanol

HRID 1243619ノート

反応式

HRID 1243619 の反応式
[F:1][C:2]([F:9])([F:8])[CH:3]([OH:7])[CH2:4][CH2:5]I.[N-:10]=[N+:11]=[N-:12].[Na+]>CS(C)=O.O>[N:10]([CH2:5][CH2:4][CH:3]([OH:7])[C:2]([F:9])([F:8])[F:1])=[N+:11]=[N-:12]

参加物

5

反応物 2

HCID 33557Sodium AzideHCID 219283571,1,1-Trifluoro-4-iodo-2-butanol

生成物 1

HCID 219283544-Azido-1,1,1-trifluoro-2-butanol収率 92.4%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

A solution of 1,1,1-trifluoro-4-iodo-2-butanol (0.604 g, 2.38 mmol) in DMSO (4 mL) was treated with sodium azide (0.178 g, 2.74 mmol) at ambient temperature, followed by heating at 50° C. for 21 h. The mixture was diluted with cold water and extracted with ethyl acetate. The combined organic extracts were washed (brine), dried, and evaporated to give the product as a pale yellow oil (0.372 g, 92%).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe combined organic extracts were washed (brine)
  3. customdried
  4. customevaporated

出典と根拠

ORDレコード
ord-071923e1e5ba49978e3e7b0c84f5c292
出典データセット
uspto-grants-2006_10
特許番号
US07119109B2

反応ノート

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