Borane → 3-Benzylamino-3-methyl-butan-1-ol
反応式
[CH2:1]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11](O)=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.B>C1COCC1>[CH2:1]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a slurry of 3-Benzylamino-3-methyl-butyric acid (1.00 g, 4.83 mmol) in THF was added borane (9.7 mmol, 9.7 mL of a 1.0 M solution in THF). After stirring for 1 h, the mixture was quenched by pouring into a mixture of 1 M HCl and crushed ice. The mixture was neutralized with K2CO3 and extracted 1× with CHCl3. The material was dried via passage through cotton and concentrated to give 441 mg (47%) of the title compound: Rf 0.40 (12:88 MeOH/CHCl3).
後処理
- customthe mixture was quenched
- additionby pouring into a mixture of 1 M HCl
- customcrushed ice
- extractionextracted 1× with CHCl3
- customThe material was dried via passage through cotton
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-f7f395e912394dbb9062091f22ecb6a2
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07119207B2
反応ノート
読み込み中…