Trifluoroacetic acid → 1,1-Dimethyl-4-nitro-butylamine trifluoroacetate

HRID 1244080ノート

反応式

HRID 1244080 の反応式
C(OC(=O)[NH:7][C:8]([CH3:16])([CH3:15])[CH2:9][CH2:10][CH2:11][N+:12]([O-:14])=[O:13])(C)(C)C.[C:18]([OH:24])([C:20]([F:23])([F:22])[F:21])=[O:19]>C(Cl)Cl>[F:21][C:20]([F:23])([F:22])[C:18]([OH:24])=[O:19].[CH3:15][C:8]([NH2:7])([CH3:16])[CH2:9][CH2:10][CH2:11][N+:12]([O-:14])=[O:13]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86587889HCID 86587889、化合物

生成物 1

HCID 219316631,1-Dimethyl-4-nitro-butylamine trifluoroacetate収率 88%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To (1,1-Dimethyl-4-nitro-butyl)-carbamic acid tert-butyl ester (1.0 g, 4.0 mmol) in 25 mL CH2Cl2 at −10° C. was added 2.5 mL TFA. The mixture was warmed to rt and monitored by TLC. When judged complete by TLC analysis, the mixture was concentrated to give the 518 mg (88%) of the title compound as an orange oil: mass spectrum m/e=147 (M+1).

後処理

  1. concentrationthe mixture was concentrated

出典と根拠

ORDレコード
ord-cf4b506976344b1b80f8586c74ed6fea
出典データセット
uspto-grants-2006_10
特許番号
US07119207B2

反応ノート

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