Allyl bromide → 1-[3-(Allyloxy)phenyl]ethanone
反応式
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]([OH:10])[CH:9]=1)=[O:3].C(=O)([O-])[O-].[K+].[K+].Br[CH2:18][CH:19]=[CH2:20]>CC(C)=O>[CH2:20]([O:10][C:8]1[CH:9]=[C:4]([C:2](=[O:3])[CH3:1])[CH:5]=[CH:6][CH:7]=1)[CH:19]=[CH2:18]参加物
5
実験手順
To solution of 3-hydroxyacetophenone (2.140 g, 15.72 mmol) in acetone (100 mL) was added potassium carbonate (4.344 g, 31.43 mmol), and 3-bromo-propene (2.282 g, 18.86 mmol) and the reaction was stirred at room temperature for 16 h. The solvent was removed in vacuo and water (25 mL) was added to the reaction mixture and then extracted with ethyl acetate (3×60 mL). The organic extracts were washed with brine (15 mL), dried (Na2SO4) and concentrated to give the title compound which was used as is in the next step.
後処理
- customThe solvent was removed in vacuo and water (25 mL)
- additionwas added to the reaction mixture
- extractionextracted with ethyl acetate (3×60 mL)
- washThe organic extracts were washed with brine (15 mL)
- dry with materialdried (Na2SO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-8d3c60a8585e4faca3a916616cb0bc63
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07119205B2
反応ノート
読み込み中…