Trifluoroacetic acid → HCID 69607355、化合物

HRID 1244158ノート

反応式

HRID 1244158 の反応式
[CH2:1]([O:3][C:4]([C:6]1[C:10]([CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][S:8][C:7]=1[NH:19]C(OC(C)(C)C)=O)=[O:5])[CH3:2].FC(F)(F)C(O)=O.C([O-])(O)=O.[Na+]>C(Cl)Cl>[CH2:1]([O:3][C:4]([C:6]1[C:10]([CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][S:8][C:7]=1[NH2:19])=[O:5])[CH3:2]

参加物

5

反応物 3

HCID 6422Trifluoroacetic acid2 回HCID 516892Sodium BicarbonateHCID 69607320HCID 69607320、化合物

生成物 1

HCID 69607355HCID 69607355、化合物収率 56%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-t-Butoxycarbonylamino-4-styryl-thiophene-3-carboxylic acid ethyl ester (0.335 g, 0.848 mmol) was dissolved in anhydrous CH2Cl2 (8 mL). This was treated with trifluoroacetic acid (0.346 mL, 4.49 mmol) and stirred at room temperature for 6 hr. More trifluoroacetic acid (0.346 mL, 4.49 mmol) was added and stirring at room temperature was continued for 30 min. The reaction was neutralized with sat. NaHCO3 (25 mL) and then extracted with CH2Cl2 (2×25 mL). The combined organic layers were washed with H2O (1×25 mL) and brine (1×25 mL). The organic layer was then dried (Na2SO4), filtered and the solvent removed in vacuo. The crude product was purified by flash chromatography (SiO2, 15 EtOAc/85 hexanes) to afford the title compound (0.1298 g, 56%) as an inseparable mixture. MS m/e (CI) 274.0 (M+H)+; 1H NMR (300 MHz, CDCl3): δ ppm 0.85 (d, 1H), 1.32 (m, 4H), 4.26 (m, 1H), 6.75 (s, 1H), 7.18 (m, 4H), 7.35 (d, 1H), 7.52 (d, 1H), 7.66 (d, 1H), 7.78 (s, 1H).

後処理

  1. stirringstirring at room temperature
  2. waitwas continued for 30 min
  3. extractionextracted with CH2Cl2 (2×25 mL)
  4. washThe combined organic layers were washed with H2O (1×25 mL) and brine (1×25 mL)
  5. dry with materialThe organic layer was then dried (Na2SO4)
  6. filtrationfiltered
  7. customthe solvent removed in vacuo
  8. customThe crude product was purified by flash chromatography (SiO2, 15 EtOAc/85 hexanes)

出典と根拠

ORDレコード
ord-4cf4efd5ad8f42a6836fc444bced04df
出典データセット
uspto-grants-2006_10
特許番号
US07119205B2

反応ノート

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