Thionyl Chloride → 6-Chloro-3-chloromethyl-4-methoxypyridazine
反応式
O=S(Cl)[Cl:3].[Cl:5][C:6]1[N:11]=[N:10][C:9]([CH2:12]O)=[C:8]([O:14][CH3:15])[CH:7]=1>C(Cl)Cl>[Cl:5][C:6]1[N:11]=[N:10][C:9]([CH2:12][Cl:3])=[C:8]([O:14][CH3:15])[CH:7]=1参加物
4
実験手順
Excess SOCl2 is added to a stirred solution of (6-chloro-4-methoxy-pyridazin-3-yl)-methanol (140 mg, 0.8 mmol) in CH2Cl2 (4 mL). The reaction mixture is stirred at room temperature for 4 hours. The solvent is removed in vacuo; toluene (4 mL) is added and evaporated to dryness. Flash column chromatography (silica gel) purification of the residue provides 6-chloro-3-chloromethyl-4-methoxy-pyridazine as a clear oil.
後処理
- customThe solvent is removed in vacuo
- additiontoluene (4 mL) is added
- customevaporated to dryness
- customFlash column chromatography (silica gel) purification of the residue
出典と根拠
- ORDレコード
- ord-7dc2075a0418446cb3fd2714965154c1
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07122546B2
反応ノート
読み込み中…