P-Chloroacetophenone → (E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

HRID 1244270

反応式

HRID 1244270 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.C(O[CH:15](OC(C)C)[N:16]([CH3:18])[CH3:17])(C)C>>[CH3:15][N:16]([CH3:18])/[CH:17]=[CH:9]/[C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:10]

参加物

3

反応物 2

HCID 7467P-ChloroacetophenoneHCID 87682N,N,N-trimethyl-1,1-bis(1-methylethoxy)amine

生成物 1

HCID 5375260(E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one

反応条件

温度
0 °C

実験手順

A solution of 1-(4-chlorophenyl)ethan-1-one (3.0 g, 19.3 mmol) and N,N, dimethylformamide diisopropylacetal (20 ml) was heated at 150° C. for 16 hours. The reaction mixture was cooled to 0° C. and treated with hexanes (20 ml). The resulting solid was collected via filtration and washed with hexanes to provide the title compound: EI-MS (m/z) 209 [M+1]+.

後処理

  1. filtrationThe resulting solid was collected via filtration
  2. washwashed with hexanes

出典と根拠

ORDレコード
ord-add7d44b36634cabbf222fc3fe0e6861
出典データセット
uspto-grants-2006_10
特許番号
US07122544B2

関連ノート

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