3-(Pyrimidin-2-yl)prop-2-yn-1-ol → 2-Pyrimidinepropanol

HRID 1244428ノート

反応式

HRID 1244428 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][OH:10]>C(OCC)(=O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][OH:10]

参加物

4

反応物 1

HCID 219193933-(Pyrimidin-2-yl)prop-2-yn-1-ol

生成物 1

HCID 109755572-Pyrimidinepropanol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

3-(2-pyrimidyl)prop-2-yn-1-ol (4.45 g, 0.033 M) was dissolved in ethyl acetate (140 mL), 10% Pd/C (890 mg) was added and the mixture stirred under an atmosphere of hydrogen for 6 hours. The reaction mixture was filtered through Celite and the filtrate evaporated to give 3-(2-pyrimidyl)propan-1-ol as a yellow oil, 4.15 g (91%). NMR (CDCl3) 2.1 (2H, m), 3.2 (2H, t), 3.8 (2H, t), 7.2 (1H, t), 8.7 (2H, d) MS found MH+ 139.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe filtrate evaporated

出典と根拠

ORDレコード
ord-0b25e8604be04407bb231ee0410487a2
出典データセット
uspto-grants-2006_10
特許番号
US07122551B2

反応ノート

読み込み中…