3-(1,3-Benzodioxol-5-yl)prop-2-enoic acid → 3-(Benzodioxol-5-yl)propionic acid
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[CH:11][C:12]([OH:14])=[O:13])=[CH:9][C:4]=2[O:3][CH2:2]1.[H][H].O1C2C=CC(CCC(N3CCCCC3)=O)=CC=2OC1>C(O)C.[Pd]>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[CH:9][C:4]=2[O:3][CH2:2]1参加物
6
実験手順
3-benzo-1,3-dioxol-5-ylacrylic acid (2 g) was hydrogenated in ethanol (50 ml) over 5% Pd-C under a pressure of hydrogen at 10 psi for 40 mins to give 3-benzo-1,3-dioxol-5-ylpropionic acid (1.67 g, 80% yield) as a solid, m.p. 86.1°-88.3° C. (Lit m.p. 87-88° C.)10 7.2 Synthesis of 3-benzo-1,3-dioxol-5-ylpropionic acid piperidide (RV-C03)
後処理
- customto give
出典と根拠
- ORDレコード
- ord-fc0143009b56424abd91a4c0528d0381
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07122561B2
反応ノート
読み込み中…