HCID 21920028、化合物 → 3-Fluoro-4-[(3-fluorophenyl)methoxy]aniline

HRID 1244568ノート

反応式

HRID 1244568 の反応式
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1>C(OCC)(=O)C.[Pt]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1

参加物

4

反応物 1

HCID 21920028HCID 21920028、化合物

生成物 1

HCID 219200533-Fluoro-4-[(3-fluorophenyl)methoxy]aniline収率 98.1%

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8857Ethyl Acetate溶媒

実験手順

12.68 g (47.8 mmol) 2-fluoro-1-(3-fluoro-benzyloxy)-4-nitro-benzene is dissolved in 150 ml ethyl acetate. 1.27 g platinum 5% on charcoal is added and the mixture is hydrogenated at RT and normal pressure for 6 hours. The catalyst is filtered off and the solution evaporated to yield 11.03 g (98%) of a dark brown liquid. MS: m/e=235.1 (M+).

後処理

  1. customis hydrogenated at RT
  2. filtrationThe catalyst is filtered off
  3. customthe solution evaporated

出典と根拠

ORDレコード
ord-7a5d4f5028cc4a92bd8a75e005e9bd57
出典データセット
uspto-grants-2006_10
特許番号
US07122562B2

反応ノート

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