Nitromethane → 4-Hydroxy-4-nitromethyl-1-(4-pyridyl)piperidine
反応式
[N+:1]([CH3:4])([O-:3])=[O:2].[Na].[N:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][C:15](=[O:18])[CH2:14][CH2:13]2)=[CH:8][CH:7]=1>CO>[OH:18][C:15]1([CH2:4][N+:1]([O-:3])=[O:2])[CH2:14][CH2:13][N:12]([C:9]2[CH:8]=[CH:7][N:6]=[CH:11][CH:10]=2)[CH2:17][CH2:16]1参加物
5
実験手順
To a solution of nitromethane (2.31 ml) in methanol (5.4 ml) was added sodium (70 mg) at ice-cooled temperature. The resulting mixture was added dropwise to a solution of 1-(4-pyridyl)-4-piperidone (5.36 g) in methanol (10.7 ml) at ice-cooled temperature for 10 minutes, and stirred for 15 hours at room temperature. The precipitate was filtered, and washed with methanol to obtain the title compound (5.31 g).
後処理
- temperaturecooled temperature
- temperaturecooled temperature for 10 minutes
- filtrationThe precipitate was filtered
- washwashed with methanol
出典と根拠
- ORDレコード
- ord-d9599f7173324e9ea78140f997f09029
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07122662B2
反応ノート
読み込み中…