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1-Hydroxybenzotriazole → 2-(6-quinolinyloxy)-2-(ethoxy)-N-(2-methylpent-3-yn-2-yl) acetamide

HRID 1244808
ノート
印刷プレビュー

反応式

HRID 1244808 の反応式
Cl.[NH2:2][C:3]([CH3:8])([CH3:7])[C:4]#[C:5][CH3:6].[N:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH:20]([O:24][CH2:25][CH3:26])[C:21](O)=[O:22])=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1.Cl.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1>CN(C)C=O.O.C(N(CC)CC)C>[N:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH:20]([O:24][CH2:25][CH3:26])[C:21]([NH:2][C:3]([CH3:8])([C:4]#[C:5][CH3:6])[CH3:7])=[O:22])=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 219231292-Methylpent-3-yn-2-amine hydrochlorideHCID 219231312-(6-Quinolinyloxy)-2-(ethoxy)acetic acid

生成物 1

HCID 692530452-(6-quinolinyloxy)-2-(ethoxy)-N-(2-methylpent-3-yn-2-yl) acetamide収率 88.7%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 8471Triethylamine溶媒

実験手順

Triethylamine (0.3 ml) was added to a stirred solution of 4-amino-4-methylpent-2-yne hydrochloride (0.054 g) in N,N-dimethylformamide (2 ml) giving a white suspension. 2-(6-Quinolinoxy)-2-(ethoxy)acetic acid (0.1 g) was added followed by N-(3-dimethylaminopropyl)-N′-ethyl carbodiimide hydrochloride (0.077 g) and a catalytic amount of 1-hydroxybenzotriazole (0.005 g), and the white suspension was stirred at ambient temperature for 18 hours. Water was added and the aqueous phase was extracted with ethyl acetate. The organic phase was washed with water, saturated aqueous sodium bicarbonate and brine, dried over magnesium sulphate and evaporated under reduced pressure to give a yellow oil (0.117 g). The oil was purified by flash chromatography (silica gel; ethyl acetate/hexane, 1:1 by volume) to give the required product (0.096 g) as a colourless oil.

後処理

  1. customgiving a white suspension
  2. extractionthe aqueous phase was extracted with ethyl acetate
  3. washThe organic phase was washed with water, saturated aqueous sodium bicarbonate and brine
  4. dry with materialdried over magnesium sulphate
  5. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-9423977cd3bd46c1b6720cb30ab8a361
出典データセット
uspto-grants-2006_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07122672B2

反応ノート

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