N,N-Dimethylaniline → (+/-)-(1-Aminomethyl-3,3-dimethyl-cyclopentyl)-acetic acid hydrochloride
反応式
[CH3:1][C:2]1([CH3:12])[CH2:11][CH2:10][C:4]2([CH2:8][NH:7][C:6](=[O:9])[CH2:5]2)[CH2:3]1.C1(C)C=CC(S(NN=CC([Cl:27])=O)(=O)=[O:20])=CC=1.CN(C)C1C=CC=CC=1.C(N(CC)CC)C>C1(C)C=CC=CC=1.C1C=CC=CC=1.C(Cl)(Cl)Cl.C(Cl)Cl>[ClH:27].[NH2:7][CH2:8][C:4]1([CH2:5][C:6]([OH:20])=[O:9])[CH2:10][CH2:11][C:2]([CH3:12])([CH3:1])[CH2:3]1参加物
9
実験手順
In step four, the alcohol 4 is treated with glyoxylic acid chloride (p-toluenesulfonyl)hydrazone and N,N-dimethylaniline followed by triethylamine in a solvent such as methylene chloride, chloroform, benzene, or toluene to give the diazoacetate 5.
出典と根拠
- ORDレコード
- ord-73cdc15d1da94f7c8c6c8531d5f9e082
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07122678B2
反応ノート
読み込み中…
