Morpholine → HCID 21912455、化合物
反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[C:9]([F:16])=[N:10][C:11]([F:15])=[N:12][C:13]=1F.C(N(CC)C(C)C)(C)C>O1CCOCC1>[Cl:7][C:8]1[C:13]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[N:12][C:11]([F:15])=[N:10][C:9]=1[F:16]参加物
5
実験手順
Morpholine (0.774 mg) was added to a solution of 5-chloro-2,4,6-trifluoropyrimidine (1.5 g), N,N-diisopropylethylamine (1.15 g) in 1,4-dioxane (30 ml) and stirred at room temperature for 16 h. The mixture was partitioned between ethyl acetate and water, the organic layer dried (MgSO4) and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 8% ethyl acetate in isohexane. Yield 0.88 g
後処理
- customThe mixture was partitioned between ethyl acetate and water
- dry with materialthe organic layer dried (MgSO4)
- customevaporated under reduced pressure
- customThe residue was purified by chromatography on silica eluting with 8% ethyl acetate in isohexane
出典と根拠
- ORDレコード
- ord-5714b6dcb91a4d8594eae8c3cece52d6
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07125881B2
反応ノート
読み込み中…