Methanol → 5-Methoxy-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
反応式
[NH2:1][C:2]([NH2:4])=[S:3].[C:5]([O:11]COC)(=O)[CH2:6][C:7]([O-:9])=O.[Na].[CH3:16][OH:17]>>[CH3:16][O:17][CH:6]1[C:5](=[O:11])[NH:4][C:2](=[S:3])[NH:1][C:7]1=[O:9]参加物
5
実験手順
Thiourea (24 g) and methoxymethyl malonate (34 g) was added to a solution of sodium (12 g) in methanol and the mixture heated under reflux for 10 h. The methanol was evaporated under reduced pressure, water (500 ml) added and extracted with ether. The aqueous layer was acidified to pH1 with conc. hydrochloric acid, evaporated to ˜200 ml and the precipitate filtered and dried. Yield 23 g
後処理
- temperaturethe mixture heated
- temperatureunder reflux for 10 h
- customThe methanol was evaporated under reduced pressure, water (500 ml)
- additionadded
- extractionextracted with ether
- customevaporated to ˜200 ml
- filtrationthe precipitate filtered
- customdried
出典と根拠
- ORDレコード
- ord-15a4e578ca8749c0905cd438242714ed
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07125881B2
反応ノート
読み込み中…