Water → tert-Butyl (5,6-dimethyl-1H-benzimidazol-2-yl)methylcarbamate

HRID 1245446

反応式

HRID 1245446 の反応式
O(C)[Na].[C:4]([CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11])#[N:5].Cl.Cl.[NH2:17][C:18]1[CH:19]=[C:20]([CH3:26])[C:21]([CH3:25])=[CH:22][C:23]=1N.O>CO>[CH3:26][C:20]1[C:21]([CH3:25])=[CH:22][C:23]2[NH:5][C:4]([CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:13])[CH3:12])=[N:17][C:18]=2[CH:19]=1

参加物

6

反応物 4

HCID 962WaterHCID 545844tert-butyl N-(cyanomethyl)carbamateHCID 122109574,5-Diamino-ortho-xylene bishydrochlorideHCID 178418582HCID 178418582、化合物

生成物 1

HCID 86760280tert-Butyl (5,6-dimethyl-1H-benzimidazol-2-yl)methylcarbamate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1.3 g of a 30% NaOCH3 solution were added to tert-butyl cyanomethylcarbamate (0.4 g; 25.6 mmol) in 10 ml of CH3OH, and the mixture was stirred at room temperature for 1 h. After addition of 5.15 g of 4,5-diamino-ortho-xylene bishydrochloride, the reaction mixture was stirred overnight and then added to 100 ml of H2O, and the solid obtained by filtration was dried at 30° C. in vacuo. 0.5 g; ESI-MS [M+H+]=276

後処理

  1. stirringthe reaction mixture was stirred overnight
  2. customthe solid obtained by filtration
  3. customwas dried at 30° C. in vacuo

出典と根拠

ORDレコード
ord-d90121ed27e544c4a8893b6b9fd7a1be
出典データセット
uspto-grants-2006_10
特許番号
US07125883B1

関連ノート

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