Trifluoroacetic acid → (1H-benzoimidazol-2-yl)piperidin-4-ylmethylamine trifluoroacetate
反応式
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[NH:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1.[C:25]([OH:31])([C:27]([F:30])([F:29])[F:28])=[O:26]>>[F:28][C:27]([F:30])([F:29])[C:25]([OH:31])=[O:26].[NH:15]1[CH2:16][CH2:17][CH:12]([CH2:11][NH:10][C:2]2[NH:1][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[N:3]=2)[CH2:13][CH2:14]1参加物
3
実験手順
) tert-Butyl 4-[(1H-benzimidazol-2-ylamino)methyl]piperidine-1-carboxylate 21b (2.65 g; 8.02 mmol) was treated with 10 ml of TFA under standard conditions. Concentration and trituration of the crude prodcut with n-pentane afforded 2.3 g; ESI-MS [M+H+]=231.15.
後処理
- concentrationConcentration and trituration of the crude prodcut with n-pentane
- customafforded 2.3 g