Sodium Carbonate → 4-(3-Phenylimidazo[1,2-a]pyridin-7-yl)benzaldehyde

HRID 1245478ノート

反応式

HRID 1245478 の反応式
I[C:2]1[N:6]2[CH:7]=[CH:8][C:9]([C:11]3[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=3)=[CH:10][C:5]2=[N:4][CH:3]=1.[C:19]1(B(O)O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.C(=O)([O-])[O-].[Na+].[Na+].[Cl-].[Li+]>O1CCOCC1>[C:19]1([C:2]2[N:6]3[CH:7]=[CH:8][C:9]([C:11]4[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][CH:12]=4)=[CH:10][C:5]3=[N:4][CH:3]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

参加物

6

反応物 4

HCID 10340Sodium Carbonate2 回HCID 66827Phenylboronic Acid2 回HCID 433294Lithium ChlorideHCID 219128644-(3-Iodoimidazo[1,2-a]pyridin-7-yl)benzaldehyde

生成物 1

HCID 219128614-(3-Phenylimidazo[1,2-a]pyridin-7-yl)benzaldehyde

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Tetrakis(triphenylphosphoine)palladium(0) (92 mg, 0.080 mmol, 0.050 equiv) was added to a deoxygenated mixture of 4-(3-iodoimidazo[1,2-a]pyridin-7-yl)benzaldehyde (2-4, 555 mg, 1.94 mmol, 1 equiv), phenyl boronic acid (486 mg, 3.99 mmol, 2.50 equiv), and aqueous saturated sodium carbonate solution (2.4 mL, 3.0 equiv) in dioxane (20 mL), and the resulting mixture was heated at reflux for 4 h. Additional tetrakis(triphenylphosphoine)palladium(0) (100 mg, 0.09 mmol, 0.05 equiv), phenyl boronic acid (500 mg, 4.0 mmol, 2.5 equiv), aqueous saturated sodium carbonate solution (2.5 mL, 3.1 equiv), and lithium chloride (200 mg, 5 mmol, 3 equiv) were added and the mixture was heated at reflux for 18 h. The reaction mixture was cooled, then concentrated, and the residue was partitioned between half-saturated aqueous NaCl solution (100 mL) and EtOAc (6×100 mL). The combined organic layers were dried over sodium sulfate and concentrated. The residue was purified by reverse-phase liquid chromotography (H2O/CH3CN gradient w/0.1% TFA) to give 4-(3-phenylimidazo[1,2-a]pyridin-7-yl)benzaldehyde (2-5) as a tan solid. LRMS m/z (M+H) Calcd 299.3, found 298.9.

後処理

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux for 4 h
  3. temperaturethe mixture was heated
  4. temperatureat reflux for 18 h
  5. temperatureThe reaction mixture was cooled
  6. concentrationconcentrated
  7. customthe residue was partitioned between half-saturated aqueous NaCl solution (100 mL) and EtOAc (6×100 mL)
  8. dry with materialThe combined organic layers were dried over sodium sulfate
  9. concentrationconcentrated
  10. customThe residue was purified by reverse-phase liquid chromotography (H2O/CH3CN gradient w/0.1% TFA)

出典と根拠

ORDレコード
ord-98944097f0ca4bb890d50fa2fdc49477
出典データセット
uspto-grants-2006_10
特許番号
US07125888B2

反応ノート

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