Nitric Acid → 6-Chloro-2,4-dihydroxy-5-methyl-3-nitropyridine
反応式
O.Cl.[Cl:3][C:4]1[NH:9][C:8](=[O:10])[CH:7]=[C:6]([OH:11])[C:5]=1[CH3:12].[N+:13]([O-])([OH:15])=[O:14]>S(=O)(=O)(O)O>[Cl:3][C:4]1[NH:9][C:8](=[O:10])[C:7]([N+:13]([O-:15])=[O:14])=[C:6]([OH:11])[C:5]=1[CH3:12]参加物
4
実験手順
A solution of 6-chloro-4-hydroxy-5-methylpyridin-2(1H)-one hydrochloride hydrate (67.0 g, 0.313 mmol) in concentrated sulfuric acid (335 mL) was cooled to ˜0° C.; nitric acid (19.6 mL of 16 M) was added dropwise over a period of ten minutes. The reaction was stirred for 20 minutes and then poured slowly into 2.5 L of ice water. A yellow precipitate formed, which was isolated by filtration and dried overnight in a vacuum oven at 60° C. to provide 39.7 g of 6-chloro-4-hydroxy-5-methyl-3-nitropyridin-2(1H)-one as a yellow solid.
後処理
- customA yellow precipitate formed
- customwhich was isolated by filtration
- customdried overnight in a vacuum oven at 60° C.
出典と根拠
- ORDレコード
- ord-1138be9161be4ae3b0eb3124eeb7d002
- 出典データセット
- uspto-grants-2006_10
- 特許番号
- US07125890B2
反応ノート
読み込み中…