Cl.[C:2]([O:5][CH2:6][C:7]1[N:8]=[C:9]([NH2:12])[S:10][CH:11]=1)(=[O:4])[CH3:3].N1C=CC=CC=1.[C:19](Cl)(=[O:21])[CH3:20].O>ClCCl>[C:2]([O:5][CH2:6][C:7]1[N:8]=[C:9]([NH:12][C:19](=[O:21])[CH3:20])[S:10][CH:11]=1)(=[O:4])[CH3:3]To a mixture of (2-amino-1,3-thiazol-4-yl)methyl acetate hydrochloride (56 g) and pyridine (45 g) in dichloromethane (560 ml) was added acetyl chloride (23 g) over a period of 30 minutes at 5° C., and the reaction mixture was stirred for 10 minutes at the same temperature. The reaction mixture was poured into water (500 ml) and extracted with chloroform (1 L). The organic layer was dried over sodium sulfate and concentrated in vacuo. The residual solid was collected by filtration with isopropyl ether to give (2-(acetylamino)-1,3-thiazol-4-yl)methyl acetate (47 g) as white crystals.
読み込み中…
