Carbonic Acid → HCID 21914754、化合物

HRID 1246432ノート

反応式

HRID 1246432 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1.N1C=CC=CC=1.[C:18](Cl)(=[O:22])[CH:19]([CH3:21])[CH3:20].C(=O)(O)O>ClCCl>[C:18]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]([O:9][CH2:10][CH3:11])=[O:8])[N:6]=1)(=[O:22])[CH:19]([CH3:21])[CH3:20]

参加物

6

反応物 4

HCID 767Carbonic AcidHCID 1049PyridineHCID 62325Isobutyryl chlorideHCID 73216Ethyl 2-aminothiazole-4-carboxylate

生成物 1

HCID 21914754HCID 21914754、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To an ice-cold mixture of ethyl 2-amino-1,3-thiazole-4-carboxylate (2 g) prepared in a similar manner according to Step 1 of the following Production Example 7, pyridine (1.3 ml) and dichloromethane (20 ml) was added isobutyryl chloride (0.91 ml) and stirred for 30 minutes. To the mixture was added saturated aqueous hydrogen bicarbonate (30 ml), and the organic layer was separated, dried over sodium sulfate and concentrated in vacuo. The crystalline residue was collected and washed with ethyl acetate to give ethyl 2-(isobutyrylamino)-1,3-thiazole-4-carboxylate (1.34 g).

後処理

  1. customprepared in a similar manner
  2. customthe organic layer was separated
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe crystalline residue was collected
  6. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-198e3aca7685453ca20b8400c5f53bff
出典データセット
uspto-grants-2006_10
特許番号
US07125901B2

反応ノート

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