Methanol → HCID 21914786、化合物

HRID 1246434ノート

反応式

HRID 1246434 の反応式
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([NH:8][C:9](=[O:13])[CH:10]([CH3:12])[CH3:11])[S:6][CH:7]=1.CO>[O-2].[Mn+4].[O-2].C(Cl)(Cl)Cl>[CH:2]([C:3]1[N:4]=[C:5]([NH:8][C:9](=[O:13])[CH:10]([CH3:11])[CH3:12])[S:6][CH:7]=1)=[O:1]

参加物

5

反応物 2

HCID 887MethanolHCID 21914755HCID 21914755、化合物

生成物 1

HCID 21914786HCID 21914786、化合物収率 70.9%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

A mixture of N-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-2-methylpropanamide (520 mg), manganese (IV) oxide (2.26 g), methanol (0.5 ml) and chloroform (5 ml) was stirred at ambient temperature for 18 hours. The reaction mixture was filtered through a celite pad, and the filtrate was concentrated in vacuo. The crystalline residue was collected and washed with diisopropyl ether to give N-(4-formyl-1,3-thiazol-2-yl)-2-methylpropanamide (365 mg).

後処理

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. concentrationthe filtrate was concentrated in vacuo
  3. customThe crystalline residue was collected
  4. washwashed with diisopropyl ether

出典と根拠

ORDレコード
ord-1a3d61a319ec42eebdf602e67cfe4c37
出典データセット
uspto-grants-2006_10
特許番号
US07125901B2

反応ノート

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