Hydrochloric Acid → 2-Acetamido-1,3-thiazole-4-carboxylic acid

HRID 1246439ノート

反応式

HRID 1246439 の反応式
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([O:12]CC)=[O:11])[N:9]=1)(=[O:3])[CH3:2].[OH-].[Na+].Cl>CO>[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10]([OH:12])=[O:11])[N:9]=1)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 702548Ethyl 2-acetamido-1,3-thiazole-4-carboxylate

生成物 1

HCID 8401132-Acetamido-1,3-thiazole-4-carboxylic acid収率 74.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of ethyl 2-(acetylamino)-1,3-thiazole-4-carboxylate (2 g), 2N sodium hydroxide (7 ml) and methanol (13 ml) was stirred at ambient temperature for 5 hours. The reaction mixture was neutralized by 1N hydrochloric acid (14 ml). The precipitated crystals were filtered and washed with water to give 2-(acetylamino)-1,3-thiazole-4-carboxylic acid (1.3 g).

後処理

  1. filtrationThe precipitated crystals were filtered
  2. washwashed with water

出典と根拠

ORDレコード
ord-28b94cc069614c5d9c137cb14ca43440
出典データセット
uspto-grants-2006_10
特許番号
US07125901B2

反応ノート

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